Posted in Projects (This page is no longer updated. See NEWS page for the latest updates), Quantitative Neurophysiology with Applied Electric Fields

Thomas Radman

I am using whole cell patch clamp to study the electrop hysiological response of single cortical cells to uniform electric field stimulation.  Cell type and morphology is reconstructed through the use of biocytin stain injection throught the recording electrode.  The long-term goal of the lab is to create an accurate in vitro model of non-invasive electrical stimulation therapies such as tDCS and TMS.

Some references:

  • Tranchina, D. and C. Nicholson, A model for the polarization of neurons by extrinsically applied electric fields. Biophys J, 1986. 50(6): p. 1139-56.
  • Ranck, J.B., Jr., Which elements are excited in electrical stimulation of mammalian central nervous system: a review. Brain Res, 1975. 98(3): p. 417-40.
  • Esser, S.K., S.L. Hill, and G. Tononi, Modeling the effects of transcranial magnetic stimulation on cortical circuits. J Neurophysiol, 2005. 94(1): p. 622-39.
  • Maccabee, P.J., et al., Magnetic coil stimulation of straight and bent amphibian and mammalian peripheral nerve in vitro: locus of excitation. J Physiol, 1993. 460: p. 201-19.