The aim of this study is to understand the effects of uniform direct current electric fields on synaptic plasticity in the motor cortex. An in-vitro rat brain slice study is designed to make extracellular electrophysiological recordings of local field potentials during the application of DC fields.
Understand the role of endogenous fields on the neuronal dynamics itself (feedback) and the effects of low amplitude (less than 10 mV/mm) electric fields on an "already active" network.
Three different models were developed to investigate the effect of high frequency stimulation on epileptiform activity in vitro. The three models are high–potassium model, picrotoxin model and the high–potassium model plus picrotoxin model.
Based on the idea of increasing the human search capacity, we are now focusing in the study of EEG signatures in free eye movement search task to accurately understand the perception of target. We are also studying the mechanism that allows for inattentional blindness.
The goal of our research is to demonstrate the physiological relevance of an algorithm that was shown to extract spectral profiles and their spatial distributions consistent with normal and cancerous tissue for routine clinical brain tumor scans.
An interaction model between a neuron and a astrocyte has been implemented. The conductance-based neuron model reproduces many different neuronal behaviors like spiking, bursting, subthreshold oscillations, spiking adaptation.
This really simple program in Matlab allows to plot a 2 variables functi on in Matlab, f(x,y), with circles with the color that codifies for the value of the function in that point.
The purpose of this purely modeling study was to analyze subthreshold voltage oscillations (SVO) in pyramidal neurons and to understand if those oscillations can be important for a fast synchronization of action potentials among neurons.
The aim of this study was to develop a bio-heat transfer model of tDCS and HD-tDCS and thereby investigate whether tDCS currents would lead to tissue temperature increases.
In this study, we sought to determine whether DBS induced electric fields will result in electroporation of endothelial monolayers and whether this (tonic) poration will lead to eventual cell death. In addition, we investigated if DBS relevant electric fields will increase transport across endothelial monolayers,electropermeation, as a result of or independent of electroporation.
We developed stimulation electrodes for reduced contact area and for safe and innocuous DC stimulation across the skin for biomedical applications including enhanced drug delivery and electrotherapy.
In order to explore the potential of HD-TES to target the subject-specific cortical areas, a new targeting software is under development to determine the optimal electrode configuration (based on MRI) and the required current flows through each electrodes (real-time current optimization).
The Multi - Channel Stimulation Interface device is designed to be used as an interface device between an isolated 2-channel current controlled DC stimulator and 5 stimulation leads.
We developed a working prototype of reflective pulse oximeter that enables surgeons to obtain real time feedback on local tissue oxygen saturation (SpO₂) during operative procedures.
The aim of this modeling study was to compare the focality (spatial extent) of induced cortical electric fields between conventional big pad tDCS and 4 X 1 ring electrode configurations.
