Projects (This page is no longer updated. See NEWS page for the latest updates)

Cellular Effects of Acute Direct Current Stimulation: Somatic and Synaptic Terminal Effects

Preprint PDF: Rahman-Cellular-Effects-Acute-DCS-Somatic-Terminal Asif Rahman J Physiol. 2013 Mar 11. Cellular Effects of Acute Direct Current Stimulation: Somatic and Synaptic Terminal Effects. Rahman A, Reato D, Arlotti M, Gasca F, Datta A, Parra LC, Bikson M. The City College of New York, CUNY; Transcranial Direct Current Stimulation (tDCS) is a non-invasive brain stimulation technique to modulate… Read more »

Computational model of neuron-astrocyte interactions during focal seizure generation

Davide Reato   The aim of this study (the paper can be found here), was to describe a new experimental model of focal epilepsy developed by the group of Giorgio Carmignoto. All the details about the experimental model can be found in Losi et al., 2010 and Gómez-Gonzalo et al., 2010. Briefly, by applying NMDA puffs, it is possible to… Read more »

Effects of DBS relevant electric fields on barrier function

Sandra Veronica Lopez-Quintero and Abhishek Datta In this study, we investigated whether DBS relevant electric fields will increase transport across endothelial monolayers. A novel system was developed for generating controlled uniform electric fields across confluent BAECS monolayers. Schematic of customized stimulation system  A microporous membrane insert with confluent cell layers was placed inside the stimulation chamber…. Read more »

Electrical Stimulation on Gamma Oscillations

Davide Reato The aim of this study was to determine the effects of electrical stimulation on gamma oscillations and the more general mechanisms by which small currents can affect neuronal activity. In particular we studied the effects of both AC and DC fields (similar to the currents induced during transcranial electrical DC stimulation, tDCs). We… Read more »

High Density Electrodes/Adapters

Varun Bansal, Jorge Vega http://www.youtube.com/v/saCX4uwInLc We developed stimulation electrodes for reduced contact area and for safe and innocuous DC stimulation across the skin for biomedical applications including enhanced drug delivery and electrotherapy. We developed electrodes and designed electrode adapters for safely applying the high density trans-cranial direct current stimulation therapy. A better design of electrode adapter… Read more »

High Frequency Electrical Stimulation on Electrographic Seizure Activity

Yuzhuo Su Three different models were developed to investigate the effect of high frequency stimulation on epileptiform activity in vitro. The three models are high–potassium model, picrotoxin model and the high–potassium model plus picrotoxin model. The modulation and suppression of epileptiform activity during (ON-effect) and after (OFF-effect) high-frequency electrical stimulation was investigated using all hippocampal slice… Read more »

Origins of Specificity during tDCS

Asif Rahman Transcranial Direct Current Stimulation (tDCS) is investigated for a broad range of neuropsychiatric indications, various rehabilitation applications, and to modulate cognitive performance in diverse tasks. Specificity of tDCS refers broadly to the ability of tDCS to produce precise, as opposed to diffuse, changes in brain function. Practically, specificity of tDCS implies application-specific customization… Read more »

Role of Cortical Cell Type and Neuronal Morphology in Uniform Electric Field Stimulation

Thomas Radman I am using whole cell patch clamp to study the electrop hysiological response of single cortical cells to uniform electric field stimulation.  Cell type and morphology is reconstructed through the use of biocytin stain injection throught the recording electrode.  The long-term goal of the lab is to create an accurate in vitro model of… Read more »

Bio-heat Transfer model of tDCS

Abhishek Datta tDCS is generally considered safe and comfortable, however isolated reports on skin irritation have suggested local scalp temperature increases as a probable cause. We have developed novel technology for tDCS that improves spatial focality at the cost of increased stimulation electrode current density; high denisty tDCS (HD-tDCS). The goal of this study was… Read more »

Developing technology to control the heating at implantable medical devices including neuroprosthetic devices

Maged Elwassif There is a growing interest in the use of Deep Brain Stimulation for the treatment of medically refractory movement disorders and other neurological and psychiatric conditions. The extent of temperature increases around DBS electrodes during normal operation (joule heating and increased metabolic activity) or coupling with an external source (e.g. MRI) remains poorly… Read more »

DIMYO

Dimitrios Boursinos   Objective The goal of this project was to build a cost efficient electromyograph (EMG) that can be connected to the computer through USB and be capable of supporting a large number of channels. Background EMG is a technique for recording the electrical activity of muscles.  An EMG detects the electrical potential generated by… Read more »

High-Density Transcranial Electrical Stimulation (HD-TES) Targeting Software Development

In order to explore the potential of HD-TES to target the subject-specific cortical areas, a new targeting software is under development to determine the optimal electrode configuration (based on MRI) and the required current flows through each electrodes (real-time current optimization). We recently introduced a paradigm shifting algorithm for automatic optimization in real time, that… Read more »

ModelMethods

Read out recent editorial on the need to control model methods.  And our review on computational models of TDS. pdf In the technical “race” to produce the fanciest models, care must be taken to ensure that that the increasingly sophisiticated work-flow continues to produce meaningful predictions. 1) Beginning with high-resolution (e.g. 1 mm) anatomical scans, the entire model… Read more »

Multi – Channel Stimulation Interface

Varun Bansal, Jorge Vega   The Multi – Channel Stimulation Interface device is designed to be used as an interface device between an isolated 2-channel current controlled DC stimulator and 5 stimulation leads. The Interface device is developed to enhance the DC stimulation targeting capabilities withhout making any changes in 2-Channel stimulator device. The multi channel Stimulation Interface… Read more »

Reflective Pulse Oximeter

UPDATES PENDING! Clinical Trials at Memorial Sloan Kettering Cancer Center are ongoing with support from NIH-NCI Next generation devices under development   Varun Bansal   We developed a working prototype of reflective pulse oximeter that enables surgeons to obtain real time feedback on local tissue oxygen saturation (SpO₂) during operative procedures. This handheld wireless pulse oximeter is… Read more »

Targeted Modulation-Comparison of conventional pad versus ring electrode configurations

Abhishek Datta The aim of this modeling study was to compare the focality (spatial extent) of induced cortical electric fields between conventional big pad tDCS and 4 X 1 ring electrode configurations. The head model was created at 1 mm X 1 mm X 1mm resolution. http://www.youtube.com/v/VX1OGyQbG6o http://www.youtube.com/v/snTRhY4uBgw Peak induced cortical electric field under rectangular… Read more »

Targeted Modulation-Workflow

Abhishek Datta    

Design, Implementation, and Performance Study of an Open Source Eye-Control System to Pilot a Parrot AR.Drone Quadrocopter

John M. Ettikkalayil Introduction  A natural user interface is a system for human-computer interaction that the user operates through intuitive actions related to everyday, natural human behavior.  There are many devices and technologies currently out there in the market that can be considered a natural user interface, such as touch screen phones and motion sensing… Read more »

EEG + Eye tracking & Visual Perception

Objective In this project the objective is to access the perception mechanism of the visual system with the ‘noisy’ but time accurate EEG recordings. We are now interested in otpimizing the capacity of human visual search in free eye movement paradigm.   Previous Work In the area of Brain Computer Interfaces (BCI) the group of… Read more »

Spectrum Separation for Brain Tumor MRSI

Yuzhuo Su Cancerous tissue exhibits altered metabolite concentrations as compared to normal brain tissue. Magnetic resonance spectroscopy imaging (MRSI) reveals such abnormalities in altered spectral profiles. Although the relations between spectral profiles and histological findings are well established, the significant variability of in vivo spectra, which is due to the heterogeneity of tumor tissues, large voxel sizes,… Read more »

Astrocyte – Neuron Interaction Model

Davide Reato Depar tment of Physics, Universita’ degli Studi di Padova, 2007 An interaction model between a neuron and a astrocyte has been implemented. The conductance-based neuron model reproduces many different neuronal behaviors like spiking, bursting, subthreshold oscillations, spiking adaptation. The interaction between the two types of cells is based on the exchange of glutamate between… Read more »

Circle Plot in MATLAB (PColor)

Davide Reato This trivial program was born in 2008 when one of my PhD collegue asked me if it was possible to plot single experimental points in a 2d space in MATLAB using a colormap. He wanted to plot “theoretical” points on a grid using the function pcolor and to plot the experimental points in… Read more »

Image to Sound Conversion (SoundImg)

Davide Reato This program create a sound using an image as the spectrogram of the sound created. The input of the program is an image, the output is a sound. If you look at the spectrogram of the sound created (using, for example, Baudline in Linux) you’ll see the image you used. The purpose of this program… Read more »

Running

Davide Reato I recently received an awesome gift: a running watch that can measure speed and heart rate (CW Kalenji 500 SD PC, in Europe you can find it at Decathlon). Since the data can be recorded and then transferred to a normal pc, I would like analyze them to see if there is a simple… Read more »

Sub-Threshold Voltage Oscillations

Davide Reato Department of Physics, Universita’ degli Studi di Padova, 2007 The purpose of this purely modeling study was to analyze subthreshold voltage oscillations (SVO) in pyramidal neurons and to understand if those oscillations can be important for a fast synchronization of action potentials among neurons. A MATLAB GUI was implemented to change the neuronal… Read more »